-
Methylation of Dual Specificity Phosphatase 4 Controls Cell Differentiation
- Authors
- Jiang, MingLuo, Minkui
- Description
Summary from GEO: "Mitogen-activated protein kinases are inactivated by dual specificity phosphatases (DUSPs), whose activities are tightly regulated during cell differentiation. Using knockdown screening and single-cell transcriptional analysis, we determined that DUSP4 is the phosphatase that specifically inactivates p38 kinase for the promotion of megakaryocyte (Mk) differentiation. Mechanistically,...
- Subject
-
Cell DifferentiationMitogen-Activated Protein KinasesMyelodysplastic SyndromesRNA-SeqSingle-Cell Analysis
- Access Rights
- Free to All
-
Cell type-dependent differential activation of ERK by oncogenic KRAS in human colon cancer and mouse intestinal epithelium
- Authors
- Brandt, RaphaelSell, ThomasLüthen, MareenUhlitz, Florian13 more author(s)...
- Description
Summary from GEO: "Mutations activating the KRAS GTPase or the BRAF kinase are frequent in colorectal cancer and are thought to constitutively activate the terminal mitogen-activated protein kinase, ERK. Using mass cytometry, we found graded phosphorylation of ERK anti-correlated with cell differentiation in patient-derived colorectal cancer organoids, and unexpectedly this gradient was observed...
- Subject
-
Cell DifferentiationColonic NeoplasmsGenes, rasMitogen-Activated Protein KinasesPhosphorylationProto-Oncogene Proteins B-rafRNA-SeqSingle-Cell Analysis
- Access Rights
- Free to All